Hydrochloric Acid → HCID 178478461、化合物

HRID 373951ノート

反応式

HRID 373951 の反応式
[Cl:1][CH2:2][CH2:3][CH2:4][C:5]#[N:6].[N-:7]=[N+:8]=[N-:9].[Na+].[Cl-].[Al+3].[Cl-].[Cl-].Cl.N=[N+]=[N-]>O1CCCC1>[Cl:1][CH2:2][CH2:3][CH2:4][C:5]1[NH:9][N:8]=[N:7][N:6]=1

参加物

7

反応物 5

HCID 313Hydrochloric AcidHCID 123364-ChlorobutyronitrileHCID 24530Hydrazoic acidHCID 33557Sodium AzideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 178478461HCID 178478461、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 4-chlorobutyronitrile, (0.05 mol) sodium azide (0.20 mol) and anhydrous aluminum chloride (0.05 mol) in 100 ml of dry tetrahydrofuran is refluxed for 24 hours. After cooling to ambient temperature the reaction is acidified with 75 ml of 15% hydrochloric acid while the hydrazoic acid generated is removed by means of an aspirator. The organic and aqueous layers are then separated and the aqueous layer extracted with ethylacetate. The combined organic extracts are dried (magnesium sulfate) and evaporated to give 5-(3-chloropropyl)tetrazole which is used directly in the next step.

後処理

  1. temperatureis refluxed for 24 hours
  2. customgenerated is removed by means of an aspirator
  3. customThe organic and aqueous layers are then separated
  4. extractionthe aqueous layer extracted with ethylacetate
  5. dry with materialThe combined organic extracts are dried (magnesium sulfate)
  6. customevaporated

出典と根拠

ORDレコード
ord-1e13144963b84e68964e7c115b7dd202
出典データセット
uspto-grants-1992_11
特許番号
US05166210

反応ノート

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