1-Fluoro-2-nitrobenzene → HCID 19809395、化合物

HRID 374094ノート

反応式

HRID 374094 の反応式
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[N:11]1([CH2:17][C:18]2[NH:19][CH:20]=[CH:21][N:22]=2)[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1.C(N(CC)C(C)C)(C)C>C(#N)C>[N:11]1([CH2:17][C:18]2[N:22]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=3[N+:8]([O-:10])=[O:9])[CH:21]=[CH:20][N:19]=2)[CH2:12][CH2:13][O:14][CH2:15][CH2:16]1

参加物

5

反応物 3

HCID 738951-Fluoro-2-nitrobenzeneHCID 81531DiisopropylethylamineHCID 2722464-(1H-imidazol-2-ylmethyl)morpholine

生成物 1

HCID 19809395HCID 19809395、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Combine 10 g of 2-fluoronitrobenzene, 13 g of 2-((4-morpholinyl)methyl)-imidazole, 18 mL of N,N-diisopropyl ethylamine, and 150 mL of acetonitrile, and heat at reflux for 48 hr. Remove the solvent under vacuum, and dissolve the residue in 500 mL of 2N H2SO4. Wash the aqueous portion with 400 mL of ether, basify with K2CO3, and extract with two 400 mL portions of CH2Cl2. Combine extracts, dry over MgSO4, charcoal treat and remove the solvent under vacuum to provide the title compound.

後処理

  1. temperatureat reflux for 48 hr
  2. customRemove the solvent under vacuum
  3. dissolutiondissolve the residue in 500 mL of 2N H2SO4
  4. washWash the aqueous portion with 400 mL of ether
  5. extractionextract with two 400 mL portions of CH2Cl2
  6. dry with materialCombine extracts, dry over MgSO4, charcoal
  7. additiontreat
  8. customremove the solvent under vacuum

出典と根拠

ORDレコード
ord-813ed3f7af024bb492fad7cd4dacb1c0
出典データセット
uspto-grants-1992_11
特許番号
US05166344

反応ノート

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