Dimethylhydantoin → Nilutamide

HRID 374126

反応式

HRID 374126 の反応式
C1(OC2C=CC=CC=2)C=CC=CC=1.[CH3:14][C:15]1([CH3:22])[NH:19][C:18](=[O:20])[NH:17][C:16]1=[O:21].[N+:23]([C:26]1[CH:31]=[CH:30][C:29](Cl)=[CH:28][C:27]=1[C:33]([F:36])([F:35])[F:34])([O-:25])=[O:24]>>[F:34][C:33]([F:35])([F:36])[C:27]1[CH:28]=[C:29]([N:17]2[C:16](=[O:21])[C:15]([CH3:22])([CH3:14])[NH:19][C:18]2=[O:20])[CH:30]=[CH:31][C:26]=1[N+:23]([O-:25])=[O:24]

参加物

4

反応物 3

HCID 6491DimethylhydantoinHCID 7583Diphenyl EtherHCID 670525-Chloro-2-nitrobenzotrifluoride

生成物 1

HCID 4493Nilutamide

反応条件

温度
190 °C

実験手順

The following were introduced into 288 ml of phenyl oxide: 96.10 grams of 5,5-dimethyl-hydantoin, 170.86 grams of 2-nitro-5-chloro trifluoromethylbenzene and 89.40 grams of cupric oxide. The mixture was heated to 190° C. for about 23 hours, then cooled to 20° C. and filtered. The residue was characterized in the phenyl oxide filtrate by thin layer chromatography.

後処理

  1. temperaturecooled to 20° C.
  2. filtrationfiltered

出典と根拠

ORDレコード
ord-250000bbc78844a9a114c6ed9b1ccd4b
出典データセット
uspto-grants-1992_11
特許番号
US05166358

関連ノート

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