Allyl bromide → N-allyl-N-(2-trifluoromethylphenyl)-2-pyridinesulfonamide 1-oxide

HRID 3750

反応式

HRID 3750 の反応式
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][S:10]([C:13]1[N+:14]([O-:19])=[CH:15][CH:16]=[CH:17][CH:18]=1)(=[O:12])=[O:11].[H-].[Na+].[CH2:24](Br)[CH:25]=[CH2:26]>CN(C=O)C>[CH2:26]([N:9]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:20])([F:1])[F:21])[S:10]([C:13]1[N+:14]([O-:19])=[CH:15][CH:16]=[CH:17][CH:18]=1)(=[O:12])=[O:11])[CH:25]=[CH2:24]

参加物

5

反応物 3

HCID 7841Allyl bromideHCID 24758Sodium hydrideHCID 20152991N-(2-trifluoromethylphenyl)-2-pyridinesulfonamide 1-oxide

生成物 1

HCID 14097714N-allyl-N-(2-trifluoromethylphenyl)-2-pyridinesulfonamide 1-oxide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To N-(2-trifluoromethylphenyl)-2-pyridinesulfonamide 1-oxide (compound 129, Table A) (1.0 g, 3.0 mmol) in 10 ml of DMF is added NaH (0.30 g, 6.2 mmol) under N2, and the mixture is stirred at RT for 30 minutes. Allyl bromide (0.82 g, 0.59 ml, 6.8 mmol) is added dropwise, and the mixture is stirred at RT for 48 hours. It is then worked up and purified to give the title compound (compound 37, Table A). (DMF is dimethylformamide; RT is room temperature.)

後処理

  1. stirringthe mixture is stirred at RT for 48 hours
  2. custompurified

出典と根拠

ORDレコード
ord-032d77276ec347c0b8611cfd56e26b51
出典データセット
uspto-grants-1988_02
特許番号
US04722749

関連ノート

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