Water → (1R*,4aR*,7aR*)-4,4-diphenylperhydrothiopyrano[2,3-c]pyrrole 1-oxide (S)-mandelate

HRID 375479ノート

反応式

HRID 375479 の反応式
[C:1]([OH:11])(=[O:10])[C@H:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3].C(#N)C.O.[C:16]1([C:22]2([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[CH:30]3[CH:26]([CH2:27][NH:28][CH2:29]3)[S:25](=[O:31])[CH2:24][CH2:23]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(#N)C.O>[C:1]([OH:11])(=[O:10])[C@H:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[OH:3].[C:32]1([C:22]2([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C@H:30]3[C@H:26]([CH2:27][NH:28][CH2:29]3)[S@:25](=[O:31])[CH2:24][CH2:23]2)[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1

参加物

6

反応物 4

HCID 962Water2 回HCID 6342AcetonitrileHCID 439616(S)-mandelic acidHCID 18995289(-)-4,4-Diphenylperhydrothiopyrano[2,3-c]pyrrole 1-oxide

生成物 1

HCID 131719251(1R*,4aR*,7aR*)-4,4-diphenylperhydrothiopyrano[2,3-c]pyrrole 1-oxide (S)-mandelate収率 19.6%

試薬・触媒・溶媒 1

HCID 18373917Acetonitrile--water (1/1)溶媒

実験手順

15.8 g of (S)-(+)-mandelic acid and 750 cm3 of a mixture of acetonitrile and water (99/1 by volume) are added to 32.3 g of (1RS,4aRS,7aRS)-4,4-diphenylperhydrothiopyrano[2,3-c]pyrrole 1-oxide, followed by 5.0 cm3 of water. After making lukewarm, the solution obtained is allowed to stand for 48 hours at room temperature. The crystalline suspension is filtered, and the filtrate, concentrated to dryness, gives a meringue which is taken up in 200 cm3 of the boiling acetonitrile-water mixture. The solution obtained is allowed to stand for about 20 hours at room temperature. The crystals are drained, washed with acetonitrile, dried and then again taken up in 200 cm3 of an acetonitrile-water mixture (98/2 by volume). The resulting solution is allowed to stand for about 20 hours at room temperature. The crystals are drained and dried. 9.4 g of (1R*,4aR*,7aR*)-4,4-diphenylperhydrothiopyrano[2,3-c]pyrrole 1-oxide (S)-(+)-mandelate are obtained; [α]D 20 =+337°(c=0 45; acetic acid)

後処理

  1. customthe solution obtained
  2. filtrationThe crystalline suspension is filtered
  3. concentrationthe filtrate, concentrated to dryness
  4. customgives a meringue which
  5. customThe solution obtained
  6. waitto stand for about 20 hours at room temperature
  7. washwashed with acetonitrile
  8. customdried
  9. waitto stand for about 20 hours at room temperature
  10. customdried

出典と根拠

ORDレコード
ord-582138e39e59410d84c0c27bb8898715
出典データセット
uspto-grants-1996_01
特許番号
US05484942

反応ノート

読み込み中…