Water → 2-(2,3-Dihydro-1-benzofuran-5-yl)ethan-1-ol

HRID 375578ノート

反応式

HRID 375578 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][C:11](O)=[O:12])=[CH:9][C:4]=2[CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>O1CCCC1>[OH:12][CH2:11][CH2:10][C:8]1[CH:7]=[CH:6][C:5]2[O:1][CH2:2][CH2:3][C:4]=2[CH:9]=1

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 27374552,3-Dihydro-5-benzofuranacetic acidHCID 21226445Aluminium lithium hydride

生成物 1

HCID 212240782-(2,3-Dihydro-1-benzofuran-5-yl)ethan-1-ol収率 73.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of (2,3-dihydro-5-benzofuranyl)acetic acid (4.9 g--see EP-A-132130) in anhydrous tetrahydrofuran (50 ml) was added dropwise over 10 minutes to a stirred suspension of lithium aluminium hydride (1.57 g) in anhydrous tetrahydrofuran (50 ml) at 0° C. The mixture was allowed to warm to room temperature and stirred for 1 hour. Water (1.5 ml) was cautiously added dropwise followed by 10% aqueous sodium hydroxide solution (1.5 ml) and water (4.5 ml). The mixture was filtered and the inorganic salts were washed with ethyl acetate. The filtrate and washings were combined and evaporated to give the title compound as an oil, (3.3 g), which was characterised by its 1H-NMR spectrum.

後処理

  1. filtrationThe mixture was filtered
  2. washthe inorganic salts were washed with ethyl acetate
  3. customevaporated

出典と根拠

ORDレコード
ord-5906822431a24b8ea04730d6939a6e27
出典データセット
uspto-grants-1996_01
特許番号
US05486527

反応ノート

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