N-bromobutanimide → HCID 18993184、化合物

HRID 375633ノート

反応式

HRID 375633 の反応式
[Br:1]N1C(=O)CCC1=O.[CH3:9][C:10]1[S:14][C:13]([CH2:15][C:16]([OH:18])=[O:17])=[CH:12][CH:11]=1>Cl(O)(=O)(=O)=O>[Br:1][CH2:9][C:10]1[S:14][C:13]([CH2:15][C:16]([OH:18])=[O:17])=[CH:12][CH:11]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 45271772-(5-methylthiophen-2-yl)acetic Acid

生成物 1

HCID 18993184HCID 18993184、化合物収率 82%

試薬・触媒・溶媒 1

HCID 24247Perchloric Acid触媒

実験手順

To a solution of N-bromosuccinimide (5.94 g, 33 mmol) in hexanes (16 mL) was added 5-methyl-2-carboxymethylthiophene (5.0 g, 32 mmol), prepared as in step 1, followed by 1 drop of perchloric acid. The reaction mixture was stirred for 22 hours at ambinet temperature and then partitioned between ethyl acetate and saturated aqueous HaHSO3 solution. The organic phase was dried over Na2SO4, filtered, and concentrated in vacuo to give 6.17 g of 5-bromomethyl-2-carboxymethylthiophene as a yellow oil.

後処理

  1. custompartitioned between ethyl acetate and saturated aqueous HaHSO3 solution
  2. dry with materialThe organic phase was dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-9a72a969e1c843cc89a85ea9a4cb1c47
出典データセット
uspto-grants-1996_01
特許番号
US05486525

反応ノート

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