Butylamine → n-Butyl-2,2,6,6-tetramethyl-4-piperidinamine

HRID 375771

反応式

HRID 375771 の反応式
[CH3:1][C:2]1([CH3:11])[CH2:7][C:6](=O)[CH2:5][C:4]([CH3:10])([CH3:9])[NH:3]1.[CH2:12]([NH2:16])[CH2:13][CH2:14][CH3:15].[H][H]>CO.[Pt]=O>[CH3:1][C:2]1([CH3:11])[CH2:7][CH:6]([NH:16][CH2:12][CH2:13][CH2:14][CH3:15])[CH2:5][C:4]([CH3:10])([CH3:9])[NH:3]1

参加物

6

反応物 3

HCID 8007ButylamineHCID 132202,2,6,6-Tetramethyl-4-piperidoneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 118285n-Butyl-2,2,6,6-tetramethyl-4-piperidinamine収率 95%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 887Methanol溶媒

実験手順

155 g of 2,2,6,6-tetramethyl-4-piperidone and 80.0 g of butylamine were dissolved in 300 ml of methanol, and then 2.0 g of platinum oxide were added to the resulting solution, after which the solution was shaken under a pressure of 3 atmospheres of hydrogen in a medium-pressure hydrogenation apparatus at room temperature for 5 hours. At the end of this time, the platinum catalyst was filtered off, and the solvent was removed from the filtrate by distillation under reduced pressure, after which the residue was further purified by distillation under reduced pressure, to yield 201.5 g of the title compound as an oil boiling at 100° to 101° C./5 mmHg (667 Pa).

後処理

  1. filtrationAt the end of this time, the platinum catalyst was filtered off
  2. customthe solvent was removed from the filtrate by distillation under reduced pressure
  3. distillationafter which the residue was further purified by distillation under reduced pressure

出典と根拠

ORDレコード
ord-1602ad3f5da84801957bfb175f8bf42b
出典データセット
uspto-grants-1996_01
特許番号
US05486556

関連ノート

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