Benzyl 4-ethoxycarbonylmethoxybutyrate → 4-Ethoxycarbonylmethoxybutyric acid

HRID 376156ノート

反応式

HRID 376156 の反応式
[CH2:1]([O:3][C:4]([CH2:6][O:7][CH2:8][CH2:9][CH2:10][C:11]([O:13]CC1C=CC=CC=1)=[O:12])=[O:5])[CH3:2]>O1CCCC1.[Pd]>[CH2:1]([O:3][C:4]([CH2:6][O:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[O:5])[CH3:2]

参加物

4

反応物 1

HCID 18991532Benzyl 4-ethoxycarbonylmethoxybutyrate

生成物 1

HCID 223185004-Ethoxycarbonylmethoxybutyric acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

45 g (0.16 mol) of benzyl 4-ethoxycarbonylmethoxybutyrate 58 g are dissolved in 450 ml of tetrahydrofuran and the solution is hydrogenated under normal pressure at room temperature by addition of 4.5 g of 5% Pd/C. Upon cessation of hydrogenation, the catalyst is removed by filtration and the filtrate is concentrated by evaporation giving 4-ethoxycarbonyhnethoxybutyric acid which is further reacted without purification.

後処理

  1. customUpon cessation of hydrogenation, the catalyst is removed by filtration
  2. concentrationthe filtrate is concentrated by evaporation

出典と根拠

ORDレコード
ord-23d5883eda0740c087ac3e2173b23940
出典データセット
uspto-grants-1996_01
特許番号
US05488140

反応ノート

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