Oxalyl chloride → (Z)-5-Fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indenylacetyl chloride

HRID 377742ノート

反応式

HRID 377742 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)/[C:7](=[CH:11]\[C:12]1[CH:17]=[CH:16][C:15]([S:18][CH3:19])=[CH:14][CH:13]=1)/[C:6]([CH3:20])=[C:5]2[CH2:21][C:22]([OH:24])=O.C(Cl)(=O)C([Cl:28])=O>C1COCC1>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)/[C:7](=[CH:11]\[C:12]1[CH:17]=[CH:16][C:15]([S:18][CH3:19])=[CH:14][CH:13]=1)/[C:6]([CH3:20])=[C:5]2[CH2:21][C:22]([Cl:28])=[O:24]

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 5352624Sulindac Sulfide

生成物 1

HCID 88255253(Z)-5-Fluoro-2-methyl-1-(4-methylthiobenzylidene)-3-indenylacetyl chloride

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

(Z)-5-fluoro-2-methyl-1-(4-methythiobenzylidene)-3-indenylacetic acid (70 mmol) in THF (500 ml) is allowed to react with oxalylchloride (2 M in CH2Cl2 ; 35 ml) under reflux conditions (24 hours). The solvent is evaporated to yield the title compound, which is used as such in the next step.

後処理

  1. customThe solvent is evaporated

出典と根拠

ORDレコード
ord-7e99e7b5e37b4901afa446cb2498d348
出典データセット
uspto-grants-2000_02
特許番号
US06028116

反応ノート

読み込み中…