(R)-2-azido-1-benzylethylamine → (2R)-3-Phenylpropane-1,2-diamine

HRID 377788

反応式

HRID 377788 の反応式
[N:1]([CH2:4][C@H:5]([NH2:13])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[N+]=[N-]>C(O)C.[Pd]>[NH2:1][CH2:4][C@H:5]([NH2:13])[CH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

参加物

4

反応物 1

HCID 14802497(R)-2-azido-1-benzylethylamine

生成物 1

HCID 12699299(2R)-3-Phenylpropane-1,2-diamine収率 103.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A sample of the compound from step 164d (1.2 g, 6.8 mmol) was hydrogenated (4 atm) in ethanol over 1.2 g of 10% Pd/C for 21.5 hours at room temperature. The mixture was filtered to remove the catalyst, and the solvent was removed to afford the title compound (1.055 g). MS m/z (M+H)+ : 151, MS m/z (M+NH4)+ : 168.

後処理

  1. customfor 21.5 hours
  2. customat room temperature
  3. filtrationThe mixture was filtered
  4. customto remove the catalyst
  5. customthe solvent was removed

出典と根拠

ORDレコード
ord-cb0c64fc139f4107a7a6cc1399c33171
出典データセット
uspto-grants-2000_02
特許番号
US06028181

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