Methanol → 3,4-Dimethylanisole

HRID 377914

反応式

HRID 377914 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[CH3:8].[CH3:10]O.[OH-].[K+].CI>O>[CH3:1][C:2]1[CH:3]=[C:4]([O:9][CH3:10])[CH:5]=[CH:6][C:7]=1[CH3:8]

参加物

6

反応物 4

HCID 887MethanolHCID 6328Methyl iodideHCID 72493,4-DimethylphenolHCID 14797Potassium Hydroxide

生成物 1

HCID 784113,4-Dimethylanisole収率 81%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 3,4-dimethylphenol(19.3 g, 0.16 mol), methanol(150 ml) and KOH(9.65 g, 0.25 mol) were added and then refluxed for 2 hrs. Methyl iodide(36.5 g, 0.25 mol) was added thereto, refluxed for 3 hours and then followed by addition of water(150 ml). The resulting mixture was extracted with ethylacetate and purified by column chromatography to obtain the titled compound.

後処理

  1. temperaturerefluxed for 2 hrs
  2. temperaturerefluxed for 3 hours
  3. extractionThe resulting mixture was extracted with ethylacetate
  4. custompurified by column chromatography

出典と根拠

ORDレコード
ord-ec61f0ce6933474899cf676405e5abcb
出典データセット
uspto-grants-2000_02
特許番号
US06028195

関連ノート

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