Trifluoroacetic acid → 1-Methoxy-4,5-dimethyl-2-nitrobenzene

HRID 377915

反応式

HRID 377915 の反応式
FC(F)(F)C(O)=O.[CH3:8][C:9]1[CH:10]=[C:11]([O:16][CH3:17])[CH:12]=[CH:13][C:14]=1[CH3:15].[N:18]([O-:20])=[O:19].[Na+]>O>[CH3:15][C:14]1[C:9]([CH3:8])=[CH:10][C:11]([O:16][CH3:17])=[C:12]([N+:18]([O-:20])=[O:19])[CH:13]=1

参加物

5

反応物 3

HCID 6422Trifluoroacetic acidHCID 784113,4-DimethylanisoleHCID 23668193Sodium Nitrite

生成物 1

HCID 193571651-Methoxy-4,5-dimethyl-2-nitrobenzene収率 55%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Trifluoroacetic acid(250 ml) was added into 3,4-dimethylanisole(17.1 g, 0.13 mol), successively sodium nitrite(16.6 g, 0.24 mol) was added slowly in water bath, and stirred at room temperature for 14 hrs. After trifluoroacetic acid was removed and water was added thereto, the resulting mixture was extracted with ether, and purified by column chromatography to obtain the titled compound.

後処理

  1. customAfter trifluoroacetic acid was removed
  2. additionwater was added
  3. extractionthe resulting mixture was extracted with ether
  4. custompurified by column chromatography

出典と根拠

ORDレコード
ord-65c7820380f148e6823b876dab1e3971
出典データセット
uspto-grants-2000_02
特許番号
US06028195

関連ノート

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