Tetrahydrofuran → 2-Methoxy-4,5-dimethylaniline

HRID 377916ノート

反応式

HRID 377916 の反応式
O1CCCC1.[CH3:6][C:7]1[C:12]([CH3:13])=[CH:11][C:10]([O:14][CH3:15])=[C:9]([N+:16]([O-])=O)[CH:8]=1>[Pd].C(O)C>[CH3:13][C:12]1[C:7]([CH3:6])=[CH:8][C:9]([NH2:16])=[C:10]([O:14][CH3:15])[CH:11]=1

参加物

5

反応物 2

HCID 8028TetrahydrofuranHCID 193571651-Methoxy-4,5-dimethyl-2-nitrobenzene

生成物 1

HCID 193571402-Methoxy-4,5-dimethylaniline収率 82%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

Tetrahydrofuran(100 ml) and ethanol(40 ml) were added into 4,5-dimethyl-2-nitroanisole(7.80 g, 0.043 mol) and then added 10% Pd/activated carbon(0.57 g) slowly, hydrogenated for 5 hrs. The reaction was completed by the same way with the above and the resulting product was purified by column chromatography to obtain the titled compound.

後処理

  1. customwas purified by column chromatography

出典と根拠

ORDレコード
ord-4c9f20c9fc284dd990bb3a0f2b887d33
出典データセット
uspto-grants-2000_02
特許番号
US06028195

反応ノート

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