Triethylamine → 2-methylthio-2-imidazoline N-ethylcarbamate

HRID 378176

反応式

HRID 378176 の反応式
[CH3:1][S:2][C:3]1[NH:4][CH2:5][CH2:6][N:7]=1.I.[CH2:9]([N:11](CC)CC)[CH3:10].C([O:18][C:19](Cl)=[O:20])C>C(Cl)Cl>[CH3:1][S:2][C:3]1[NH:7][CH2:6][CH2:5][N:4]=1.[CH2:9]([NH:11][C:19](=[O:20])[O-:18])[CH3:10]

参加物

6

反応物 4

HCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 24841Hydrogen iodideHCID 883692-Methylthio-2-imidazoline hydroiodide

生成物 1

HCID 867551732-methylthio-2-imidazoline N-ethylcarbamate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To 2-methylthio-2-imidazoline.HI (Aldrich) (10 g, 0.041 mole) and triethylamine (8.3 g, 0.0082 mole) in CH2Cl2 (50 mL) was added ethylchloroformate (Aldrich) (4.5 g, 0.041 mole) dropwise at ice bath temperature. The reaction was stirred overnight at room temperature. The precipitate was filtered and washed with CH2Cl2. The CH2Cl2 from the filtrate was washed with H2O (3×), dried over MgSO4 and removed under vacuum to yield 2-methylthio-2-imidazoline-N-ethylcarbamate (7.1 g) as a clear yellow oil.

後処理

  1. filtrationThe precipitate was filtered
  2. washwashed with CH2Cl2
  3. washThe CH2Cl2 from the filtrate was washed with H2O (3×)
  4. dry with materialdried over MgSO4
  5. customremoved under vacuum

出典と根拠

ORDレコード
ord-f00a8f047563487b9aac4f53e5631c5c
出典データセット
uspto-grants-2000_02
特許番号
US06028223

関連ノート

読み込み中…