Sodium Hydroxide → 2-(Propylthio)pyrimidine-4,6-diol

HRID 378841

反応式

HRID 378841 の反応式
[CH2:1](I)[CH2:2][CH3:3].[OH:5][C:6]1[CH:11]=[C:10]([OH:12])[N:9]=[C:8]([SH:13])[N:7]=1.[OH-].[Na+]>O>[OH:5][C:6]1[CH:11]=[C:10]([OH:12])[N:9]=[C:8]([S:13][CH2:1][CH2:2][CH3:3])[N:7]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 336431-IodopropaneHCID 178516656HCID 178516656、化合物

生成物 1

HCID 1784608102-(Propylthio)pyrimidine-4,6-diol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Propyl iodide (136 ml) was added to a suspension of 4,6-dihydroxy-2-mercaptopyrimidine (200 g) in water (800 ml), containing sodium hydroxide (55.6 g). The reaction mixture was stirred for 2 weeks then concentrated to half volume, 2N hydrochloric acid was added and the subtitle compound was isolated by filtration (167 g).

後処理

  1. concentrationthen concentrated to half volume, 2N hydrochloric acid
  2. additionwas added

出典と根拠

ORDレコード
ord-6e83b0f2d6c14146a36cb58912dd272d
出典データセット
uspto-grants-2001_10
特許番号
US06297232B1

関連ノート

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