Potassium Carbonate → 2(1H)-Pyridinone, 1-(2-methoxyphenyl)-

HRID 379072

反応式

HRID 379072 の反応式
I[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9].[OH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1.C([O-])([O-])=O.[K+].[K+]>[Cu].CCOC(C)=O>[O:10]=[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]1[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9]

参加物

6

反応物 3

HCID 11430Potassium CarbonateHCID 68257o-IodoanisoleHCID 178516071HCID 178516071、化合物

生成物 1

HCID 121913892(1H)-Pyridinone, 1-(2-methoxyphenyl)-

試薬・触媒・溶媒 2

HCID 23978Copper触媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
200 °C

実験手順

2-Iodoanisole (1.30 mL, 0.01 mol), 2-hydroxypyridine (0.95 g, 0.01 mol), anhydrous K2CO3 (2.76 g, 0.02 mol) and copper powder (0.0636 g, 0.001 mol) were combined and heated at 200° C. for 2 hr. The reaction mixture was cooled, EtOAc added, and filtered. The filtrate was washed with H2O, aqueous saturated NaHCO3 solution, brine, and dried (Na2SO4). Filtration and concentration gave the title compound after chromatography (silica gel, 2% CH3OH, CH2Cl2).

後処理

  1. temperatureThe reaction mixture was cooled
  2. filtrationfiltered
  3. washThe filtrate was washed with H2O, aqueous saturated NaHCO3 solution, brine
  4. dry with materialdried (Na2SO4)
  5. filtrationFiltration and concentration

出典と根拠

ORDレコード
ord-4c3a55ba796041aab00b78a70ae21ba3
出典データセット
uspto-grants-2001_10
特許番号
US06297239B1

関連ノート

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