Potassium Iodide → 2-(3-Bromophenoxy)acetamide

HRID 380008ノート

反応式

HRID 380008 の反応式
Cl[CH2:2][C:3]([NH2:5])=[O:4].[Br:6][C:7]1[CH:8]=[C:9]([OH:13])[CH:10]=[CH:11][CH:12]=1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(#N)C>[Br:6][C:7]1[CH:8]=[C:9]([CH:10]=[CH:11][CH:12]=1)[O:13][CH2:2][C:3]([NH2:5])=[O:4]

参加物

6

反応物 4

HCID 4875Potassium IodideHCID 6580ChloroacetamideHCID 11430Potassium CarbonateHCID 115633-Bromophenol

生成物 1

HCID 78183782-(3-Bromophenoxy)acetamide収率 103.8%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 2-chloroacetamide (5.6 g), 3-bromophenol (10 g), potassium carbonate (8.3 g) and potassium iodide (1 g) in acetonitrile was stirred at room temperature for 72 hours. The resulting mixture was filtered, and the solids washed with ethyl acetate, and then water. The dried solids were recrystallised from boiling ethanol: water(8:2) to give the sub-title compound as a solid (13.8 g).

後処理

  1. filtrationThe resulting mixture was filtered
  2. washthe solids washed with ethyl acetate
  3. customThe dried solids were recrystallised

出典と根拠

ORDレコード
ord-763d6c90d8df49af866b04a4a9d681f2
出典データセット
uspto-grants-2001_10
特許番号
US06300352B1

反応ノート

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