Ethanol → 5-Bromo-o-toluidine

HRID 380040

反応式

HRID 380040 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([N+:8]([O-])=O)[CH:7]=1.[Cl-].[NH4+].C(O)C.[OH-].[Na+]>[Fe].O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([CH:7]=1)[NH2:8]

参加物

7

反応物 4

HCID 702EthanolHCID 14798Sodium HydroxideHCID 25517Ammonium ChlorideHCID 1235464-Bromo-2-nitrotoluene

生成物 1

HCID 27348055-Bromo-o-toluidine収率 102.2%

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 962Water溶媒

実験手順

A slurry of 5-bromo-2-methylnitrobenzene (3.00 g), iron powder (3.11 g), and ammonium chloride (2.97 g), in 3:1 ethanol : water (50 ml) was heated at reflux temperature for 1 hour. The mixture was poured into 10% aqueous sodium hydroxide and filtered through Celite®. The filtrate was then extracted with ethyl acetate, the extracts washed with brine, dried over magnesium sulfate, filtered and evaporated to afford the subtitle compound as an oil (2.64 g).

後処理

  1. temperatureat reflux temperature for 1 hour
  2. filtrationfiltered through Celite®
  3. extractionThe filtrate was then extracted with ethyl acetate
  4. washthe extracts washed with brine
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. customevaporated

出典と根拠

ORDレコード
ord-0afe2c257b8f4b8fba79f5c0eb0868fb
出典データセット
uspto-grants-2001_10
特許番号
US06300352B1

関連ノート

読み込み中…