Lawesson's reagent → 3-Amino-2-thiophenecarbothioamide

HRID 380394

反応式

HRID 380394 の反応式
[NH2:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([NH2:9])=O.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:19])=CC=1>O1CCCC1>[NH2:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7](=[S:19])[NH2:9]

参加物

4

反応物 2

HCID 87949Lawesson's reagentHCID 5189933-Aminothiophene-2-carboxamide

生成物 1

HCID 143211023-Amino-2-thiophenecarbothioamide収率 57.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 3-aminothiophene-2-carboxamide (4.5 g, 31 mmol) in tetrahydrofuran was treated with Lawesson's Reagent (7.7 g, 190 mmol) and the solution was stirred at room temperature for 18 h. The solvent was removed and the residue purified by chromatography on silica gel using dichloromethane as eluent. The product was obtained as a yellow powder (2.8 g, 56%), m.p. 98-99° C.

後処理

  1. customThe solvent was removed
  2. customthe residue purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-b8dbf243a8a842919d2cafadcf065e20
出典データセット
uspto-grants-2001_10
特許番号
US06303613B1

関連ノート

読み込み中…