Calcium Hydroxide → 2-Chloro-5-methylsulphinyl-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide

HRID 380692

反応式

HRID 380692 の反応式
[Cl:1][C:2]1[CH:21]=[CH:20][C:19]([S:22][CH3:23])=[CH:18][C:3]=1[C:4]([NH:6][CH2:7][C:8]12[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][CH:10]([CH2:11]3)[CH2:9]1)[CH2:15]2)=[O:5].ClC1C(C(OO)=[O:32])=CC=CC=1.[OH-].[Ca+2].[OH-]>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:21]=[CH:20][C:19]([S:22]([CH3:23])=[O:32])=[CH:18][C:3]=1[C:4]([NH:6][CH2:7][C:8]12[CH2:17][CH:12]3[CH2:11][CH:10]([CH2:16][CH:14]([CH2:13]3)[CH2:15]1)[CH2:9]2)=[O:5]

参加物

5

反応物 3

HCID 6093208Calcium HydroxideHCID 89239442-Chloro-5-methylthio-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamideHCID 125873982-Chlorobenzene-1-carboperoxoic acid

生成物 1

HCID 183815322-Chloro-5-methylsulphinyl-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide収率 110%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A solution of amide from Example 38 (0.2 g) in chloroform (5 ml) was treated with 70% m chloroperbenzoic acid (0.14 g). The reaction mixture was stirred for two days. calcium hydroxide (0.09 g) added and after stirring for a further 0.5 h the mixture was filtered. The filtrate was concentrated under reduced pressure to yield the sub-title product as a white solid (0.23 g).

後処理

  1. stirringafter stirring for a further 0.5 h the mixture
  2. filtrationwas filtered
  3. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-f5da5005bfa940d3b798bbdd636528de
出典データセット
uspto-grants-2001_10
特許番号
US06303659B2

関連ノート

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