Oxalyl chloride → 5-Chlorothiophene-2-carbonyl Chloride

HRID 38132

反応式

HRID 38132 の反応式
[Cl:1][C:2]1[S:6][C:5]([C:7]([OH:9])=O)=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:13])=O>CCOC(C)=O.CN(C=O)C>[Cl:1][C:2]1[S:6][C:5]([C:7]([Cl:13])=[O:9])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 950485-Chloro-2-thiophenecarboxylic acid

生成物 1

HCID 5892235-Chlorothiophene-2-carbonyl Chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a chilled solution of 5-chlorothiophene-2-carboxylic acid (0.16 g, 1.0 mmol) in EtOAc (3 mL) and DMF (1 drop) was added neat oxalyl chloride (92 μL, 1.05 mmol). The reaction mixture was stirred cold for 2 hr and concentrated in vacuo to give crude 5-chlorothiophene-2-carbonyl chloride.

後処理

  1. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-f3ab523db84d4747a39bf21f2f7e9033
出典データセット
uspto-grants-2013_09
特許番号
US08524721B2

関連ノート

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