Oxalyl chloride → 5-Chlorothiophene-2-carbonyl Chloride
反応式
[Cl:1][C:2]1[S:6][C:5]([C:7]([OH:9])=O)=[CH:4][CH:3]=1.C(Cl)(=O)C([Cl:13])=O>CCOC(C)=O.CN(C=O)C>[Cl:1][C:2]1[S:6][C:5]([C:7]([Cl:13])=[O:9])=[CH:4][CH:3]=1参加物
5
実験手順
To a chilled solution of 5-chlorothiophene-2-carboxylic acid (0.16 g, 1.0 mmol) in EtOAc (3 mL) and DMF (1 drop) was added neat oxalyl chloride (92 μL, 1.05 mmol). The reaction mixture was stirred cold for 2 hr and concentrated in vacuo to give crude 5-chlorothiophene-2-carbonyl chloride.
後処理
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-f3ab523db84d4747a39bf21f2f7e9033
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524721B2
反応ノート
読み込み中…