Benzoyl chloride → N-(2-methyl-4-nitrophenyl)benzamide

HRID 38146

反応式

HRID 38146 の反応式
[CH3:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[C:12](Cl)(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:3]=1[NH:4][C:12](=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 7412Benzoyl chlorideHCID 74412-Methyl-4-nitroaniline

生成物 1

HCID 2835288N-(2-methyl-4-nitrophenyl)benzamide収率 95%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a suspension of 2-methyl-4-nitroaniline (0.76 g, 5 mmol) in toluene (25 mL) was added neat benzoyl chloride (0.59 mL, 5.08 mmol). The reaction mixture was refluxed for 16 hr, cooled and filtered to give N-(2-methyl-4-nitrophenyl)benzamide (1.21 g, 95%) as a beige solid. ES-MS (M+H)+=257.

後処理

  1. temperatureThe reaction mixture was refluxed for 16 hr
  2. temperaturecooled
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-cfb21d133e044f9098f617d99185e3d2
出典データセット
uspto-grants-2013_09
特許番号
US08524721B2

関連ノート

読み込み中…