Stearic Acid → 1H-Indole-2-carboxylic acid, 3-(1-oxododecyl)-, ethyl ester

HRID 382827ノート

反応式

HRID 382827 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([O:12][CH2:13][CH3:14])=[O:11].[C:15](O)(=[O:33])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]CCCCCC.FC(F)(F)C(OC(=O)C(F)(F)F)=O.[OH-].[Na+]>C(Cl)Cl>[C:15]([C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][C:2]=1[C:10]([O:12][CH2:13][CH3:14])=[O:11])(=[O:33])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]

参加物

6

反応物 4

HCID 5281Stearic AcidHCID 9845Trifluoroacetic anhydrideHCID 14798Sodium HydroxideHCID 73125Ethyl indole-2-carboxylate

生成物 1

HCID 106192401H-Indole-2-carboxylic acid, 3-(1-oxododecyl)-, ethyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 3.8 g (20 mmol) of ethyl indole-2-carboxylate, 6.0 g (30 mmol) of octadecanoic acid, 1.0 g of polyphosphoric acid, 20 ml of absol. CH2Cl2 and 4.4 ml of trifluoroacetic anhydride is stirred at room temperature for 4 h. Then 1 M NaOH is added, and the mixture is extracted with ether. The ether phase is dried over Na2SO4 and the solvent is distilled off. The product precipitates after addition of petroleum ether.

後処理

  1. extractionthe mixture is extracted with ether
  2. dry with materialThe ether phase is dried over Na2SO4
  3. distillationthe solvent is distilled off
  4. customThe product precipitates
  5. additionafter addition of petroleum ether

出典と根拠

ORDレコード
ord-0563c47bc0a54358ac6a36e284a2ab80
出典データセット
uspto-grants-2001_10
特許番号
US06310217B1

反応ノート

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