Ammonium formate → (4-Amino-2-phenylbenzoyl)methionine 2-trimethylsilylethyl ester

反応式

[CH3:1][Si:2]([CH3:32])([CH3:31])[CH2:3][CH2:4][O:5][C:6](=[O:30])[C@H:7]([CH2:26][CH2:27][S:28][CH3:29])[NH:8][C:9](=[O:25])[C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][C:11]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C([O-])=O.[NH4+]>CO.[Pd]>[CH3:32][Si:2]([CH3:1])([CH3:31])[CH2:3][CH2:4][O:5][C:6](=[O:30])[C@H:7]([CH2:26][CH2:27][S:28][CH3:29])[NH:8][C:9](=[O:25])[C:10]1[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][C:11]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

実験手順

A mixture of the product of Example 283A (8.85 g, 25.8 mmol), ammonium formate (4.88 g, 77.4 mmol) and palladium (10%) on carbon (1 g) in methanol was refluxed for 5 hours. The mixture was then filtered through Celite and rinsed with ethyl acetate. The filtrate was diluted with ethyl acetate, washed with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to give the title compound which was used without further purification.