4-Ethylaniline → 2-Bromo-4-ethylaniline
反応式
[CH2:1]([C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1)[CH3:2].C1C(=O)N([Br:17])C(=O)C1>CN(C=O)C>[Br:17][C:5]1[CH:4]=[C:3]([CH2:1][CH3:2])[CH:9]=[CH:8][C:6]=1[NH2:7]参加物
4
反応条件
- 温度
- 0 °C
実験手順
To 4-ethylaniline (1.76 g, 14.52 mmol) and NBS (2.58 g, 14.52 mmol) was added DMF (67 mL) and the reaction mixture was stirred at 0° C. for 10 min. The reaction mixture was purified by silica gel chromatography (0-50% ethyl acetate/hexanes) to provide 2-bromo-4-ethylaniline (2.7 g, 93% yield). LC/MS m/z 201.0 [M+H]+.
後処理
- customThe reaction mixture was purified by silica gel chromatography (0-50% ethyl acetate/hexanes)
出典と根拠
- ORDレコード
- ord-f2dfb514a71b4220af48278e933e8db1
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08367660B2
反応ノート
読み込み中…