Formaldehyde → Benzothiazoline

HRID 385003ノート

反応式

HRID 385003 の反応式
[CH2:1]=O.[NH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[SH:10]>O.C(OC(C)C)(C)C>[S:10]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][CH2:1]1

参加物

5

反応物 2

HCID 712FormaldehydeHCID 87132-Aminothiophenol

生成物 1

HCID 96588Benzothiazoline

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 7914Diisopropyl Ether溶媒

実験手順

37% formalin (5.2 mL) was diluted with water (80 mL), and diisopropylether (80 mL) and 2-aminobenzenethiol (7.84 g) were added, and then the mixture was stirred at mom temperature for 30 minutes. The organic layer was separated and the aqueous layer was extracted with diisopropylether. The organic layers were combined, washed with saturated brine and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure and the obtained residue was used for the synthesis of (c).

後処理

  1. additionwere added
  2. customThe organic layer was separated
  3. extractionthe aqueous layer was extracted with diisopropylether
  4. washwashed with saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. distillationThe solvent was distilled off under reduced pressure
  7. customthe obtained residue was used for the synthesis of (c)

出典と根拠

ORDレコード
ord-4cda6bdfc23841e0bd7e15558c15bc40
出典データセット
uspto-grants-2013_02
特許番号
US08367843B2

反応ノート

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