N-bromobutanimide → 5-Bromo-3-cyclobutyl-2-hydroxybenzaldehyde

HRID 385047ノート

反応式

HRID 385047 の反応式
[CH:1]1([C:5]2[C:6]([OH:13])=[C:7]([CH:10]=[CH:11][CH:12]=2)[CH:8]=[O:9])[CH2:4][CH2:3][CH2:2]1.[Br:14]N1C(=O)CCC1=O>C(#N)C>[Br:14][C:11]1[CH:12]=[C:5]([CH:1]2[CH2:2][CH2:3][CH2:4]2)[C:6]([OH:13])=[C:7]([CH:10]=1)[CH:8]=[O:9]

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 866681553-Cyclobutyl-2-hydroxybenzaldehyde

生成物 1

HCID 866681565-Bromo-3-cyclobutyl-2-hydroxybenzaldehyde

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

3-cyclobutyl-2-hydroxybenzaldehyde (2.29 g) was dissolved in acetonitrile (30 mL), and N-bromosuccinimide (5.10 g) was added to the solution at 0° C., and then the mixture was stirred at room temperature for 4 hours. The solvent was distilled off under reduced pressure and water was added, and then the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure and the obtained residue was used for the synthesis of (d).

後処理

  1. distillationThe solvent was distilled off under reduced pressure and water
  2. additionwas added
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe organic layer was washed with water and saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. distillationThe solvent was distilled off under reduced pressure
  7. customthe obtained residue was used for the synthesis of (d)

出典と根拠

ORDレコード
ord-df13c2e0b65d4849a1d3ae9ff29bd0b8
出典データセット
uspto-grants-2013_02
特許番号
US08367843B2

反応ノート

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