Toluene → 3-Cyano-4-methoxybenzoyl chloride

HRID 385134

反応式

HRID 385134 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:6](O)=[O:7])#[N:2].C1(C)C=CC=CC=1.S(Cl)([Cl:23])=O>CN(C)C=O>[C:1]([C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:6]([Cl:23])=[O:7])#[N:2]

参加物

5

反応物 3

HCID 1140TolueneHCID 24386Thionyl ChlorideHCID 219909723-Cyano-4-methoxybenzoic acid

生成物 1

HCID 202549413-Cyano-4-methoxybenzoyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

To 3-cyano-4-methoxybenzoic acid (1.78 g), toluene (20 mL), N,N-dimethylformamide (3 droplets) and thionyl chloride (1.14 mL) were added, and then the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and the obtained residue was azeotroped with toluene and used for the synthesis of (d).

後処理

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe obtained residue was azeotroped with toluene
  3. customused for the synthesis of (d)

出典と根拠

ORDレコード
ord-ddd393383c0b4ed59530ffcd6f1c55e5
出典データセット
uspto-grants-2013_02
特許番号
US08367843B2

関連ノート

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