Toluene → 3-Cyano-4-methoxybenzoyl chloride
反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:6](O)=[O:7])#[N:2].C1(C)C=CC=CC=1.S(Cl)([Cl:23])=O>CN(C)C=O>[C:1]([C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:6]([Cl:23])=[O:7])#[N:2]参加物
5
反応条件
- 温度
- 60 °C
実験手順
To 3-cyano-4-methoxybenzoic acid (1.78 g), toluene (20 mL), N,N-dimethylformamide (3 droplets) and thionyl chloride (1.14 mL) were added, and then the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and the obtained residue was azeotroped with toluene and used for the synthesis of (d).
後処理
- distillationThe solvent was distilled off under reduced pressure
- customthe obtained residue was azeotroped with toluene
- customused for the synthesis of (d)
出典と根拠
- ORDレコード
- ord-ddd393383c0b4ed59530ffcd6f1c55e5
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08367843B2
反応ノート
読み込み中…