Triethylamine → 4-Ethoxy-2-pyrrolidin-1-ylpyrimidine

HRID 386096ノート

反応式

HRID 386096 の反応式
Cl[C:2]1[N:7]=[C:6]([O:8][CH2:9][CH3:10])[CH:5]=[CH:4][N:3]=1.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1.CCN(CC)CC>C1COCC1>[CH2:9]([O:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[N:7]=1)[CH3:10]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31268PyrrolidineHCID 47372802-Chloro-4-ethoxypyrimidine

生成物 1

HCID 595258964-Ethoxy-2-pyrrolidin-1-ylpyrimidine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2-chloro-4-ethoxypyrimidine (3 g, 19 mol) in THF (410 mL) was added pyrrolidine (2.7 g, 38 mmol) and Et3N (5.8 g, 57 mmol) and the reaction mixture was heated to reflux overnight. The solvent was evaporated and the residue was partioned between water and EtOAc. The aqueous phase was extracted with EtOAc. The combined organic phases were dried over sodium sulfate, filtered, and concentrated to give the title compound.

後処理

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux overnight
  3. customThe solvent was evaporated
  4. extractionThe aqueous phase was extracted with EtOAc
  5. dry with materialThe combined organic phases were dried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-7a911ec2b8604f458f43e5d3f63a6713
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

反応ノート

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