4-Hydroxybenzaldehyde → 3-Buten-2-one, 4-(4-hydroxyphenyl)-

HRID 38664

反応式

HRID 38664 の反応式
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[CH3:10][C:11]([CH3:13])=[O:12]>[OH-].[Na+]>[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[CH:10][C:11](=[O:12])[CH3:13])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 1264-HydroxybenzaldehydeHCID 180Acetone

生成物 1

HCID 956483-Buten-2-one, 4-(4-hydroxyphenyl)-収率 70.4%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒2 回

実験手順

4-Hydroxybenzaldehyde (10 g, 82 mmol) was dissolved in 28 ml of 10% sodium hydroxide aqueous solution, then acetone (20 ml) and 10% sodium hydroxide aqueous solution (40 ml) was added under stirring, and the reaction mixture was stirred for 6 hr at room temperature. separated solid diluted with water until all separated solid dissolved. The reaction mixture was neutralized with hydrochloric acid to pH=7.0. The precipitated solid was collected by filtration and washed with water and ethanol successively. The crude product was recrystallized from ethanol to give 9.3 g of a pale yellow solid, mp: 104-105° C., yield: 70.4%.

後処理

  1. stirringthe reaction mixture was stirred for 6 hr at room temperature
  2. customseparated solid
  3. additiondiluted with water until all separated solid
  4. dissolutiondissolved
  5. filtrationThe precipitated solid was collected by filtration
  6. washwashed with water and ethanol successively
  7. customThe crude product was recrystallized from ethanol

出典と根拠

ORDレコード
ord-f526c903b5bf482daf69f8cfb513b16b
出典データセット
uspto-grants-2013_09
特許番号
US08524744B2

関連ノート

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