4-Hydroxybenzaldehyde → 3-Buten-2-one, 4-(4-hydroxyphenyl)-
反応式
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[CH3:10][C:11]([CH3:13])=[O:12]>[OH-].[Na+]>[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[CH:10][C:11](=[O:12])[CH3:13])=[CH:4][CH:3]=1参加物
4
実験手順
4-Hydroxybenzaldehyde (10 g, 82 mmol) was dissolved in 28 ml of 10% sodium hydroxide aqueous solution, then acetone (20 ml) and 10% sodium hydroxide aqueous solution (40 ml) was added under stirring, and the reaction mixture was stirred for 6 hr at room temperature. separated solid diluted with water until all separated solid dissolved. The reaction mixture was neutralized with hydrochloric acid to pH=7.0. The precipitated solid was collected by filtration and washed with water and ethanol successively. The crude product was recrystallized from ethanol to give 9.3 g of a pale yellow solid, mp: 104-105° C., yield: 70.4%.
後処理
- stirringthe reaction mixture was stirred for 6 hr at room temperature
- customseparated solid
- additiondiluted with water until all separated solid
- dissolutiondissolved
- filtrationThe precipitated solid was collected by filtration
- washwashed with water and ethanol successively
- customThe crude product was recrystallized from ethanol
出典と根拠
- ORDレコード
- ord-f526c903b5bf482daf69f8cfb513b16b
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524744B2
反応ノート
読み込み中…