Acetone → 4-(4-Methylphenyl)-3-buten-2-one

HRID 38665

反応式

HRID 38665 の反応式
O.[OH-].[Na+].[CH3:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]=O)=[CH:7][CH:6]=1.Cl.[CH3:14][C:15]([CH3:17])=[O:16]>>[CH3:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[CH:14][C:15](=[O:16])[CH3:17])=[CH:7][CH:6]=1

参加物

6

反応物 5

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 962WaterHCID 77254-MethylbenzaldehydeHCID 14798Sodium Hydroxide

生成物 1

HCID 1073884-(4-Methylphenyl)-3-buten-2-one収率 45.6%

実験手順

Water (20 ml) and 10% NaOH aqueous solution (4 ml) were added under stirring to the solution of 4-methylbenzaldehyde (10.2 g, 10 mmol) in acetone (10 ml). The reaction mixture was stirred for 14 hr at room temperature, then the pH value was adjusted to pH=7.0 with 10% hydrochloric acid, extracted with methylene chloride. The combined methylene chloride extract was washed with water, dried over anhydrous sodium sulfate, filtered and concentrated to give 0.73 g of a yellow viscous oil, yield: 45.6%.

後処理

  1. extractionextracted with methylene chloride
  2. extractionThe combined methylene chloride extract
  3. washwas washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-454981ae6c944075b3f892a7abf49cbe
出典データセット
uspto-grants-2013_09
特許番号
US08524744B2

関連ノート

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