Potassium Hydroxide → 8-(2-Methoxy-4-benzyloxy-phenyl)-2-benzyloxypurine

HRID 3870

反応式

HRID 3870 の反応式
[OH-:1].[K+].[CH3:3][O:4][C:5]1[CH:10]=[C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:8]=[CH:7][C:6]=1[C:19]1[NH:27][C:26]2[C:21](=[N:22][C:23](Cl)=[N:24][CH:25]=2)[N:20]=1>C(O)C1C=CC=CC=1>[CH3:3][O:4][C:5]1[CH:10]=[C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:8]=[CH:7][C:6]=1[C:19]1[NH:27][C:26]2[C:21](=[N:22][C:23]([O:1][CH2:19][C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][CH:5]=3)=[N:24][CH:25]=2)[N:20]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 135323868-(2-Methoxy-4-benzyloxy-phenyl)-2-chloro-purine

生成物 1

HCID 135323998-(2-Methoxy-4-benzyloxy-phenyl)-2-benzyloxypurine

試薬・触媒・溶媒 1

HCID 244Benzyl Alcohol溶媒

反応条件

温度
150 °C

実験手順

An amount of 4.5 gm of powdered potassium hydroxide is dissolved in 70 ml of benzyl alcohol, and then 7.2 gm of 8-(2-methoxy-4-benzyloxy-phenyl)-2-chloro-purine are added. The mixture is heated to 150° C. for three hours, cooled, and filtered, the filtrate is mixed with ether, and the precipitate obtained is purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:2.5)].

後処理

  1. temperaturecooled
  2. filtrationfiltered
  3. additionthe filtrate is mixed with ether
  4. customthe precipitate obtained
  5. customis purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:2.5)]

出典と根拠

ORDレコード
ord-18a6059416844248a8ba411c923fd244
出典データセット
uspto-grants-1988_02
特許番号
US04722929

関連ノート

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