Methyl chloroformate → Methyl[2-(2-bromophenyl)ethyl]carbamate

HRID 387657

反応式

HRID 387657 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][NH2:10].C(=O)([O-])[O-].[K+].[K+].[C:17](Cl)(=[O:20])[O:18][CH3:19]>O1CCCC1>[CH3:19][O:18][C:17](=[O:20])[NH:10][CH2:9][CH2:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Br:1]

参加物

5

反応物 3

HCID 6586Methyl chloroformateHCID 11430Potassium CarbonateHCID 27340912-Bromophenethylamine

生成物 1

HCID 59401358Methyl[2-(2-bromophenyl)ethyl]carbamate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

5 g of 2-(2-bromophenyl)ethanamine and 10 g of potassium carbonate in 30 cm3 of anhydrous tetrahydrofuran are stirred under an inert atmosphere at a temperature close to 10° C. 2.5 cm3 of methyl chlorocarbonate in solution in 10 cm3 of tetrahydrofuran are poured into the reaction mixture. After returning to a temperature close to 20° C., the reaction mixture is heated for 2 h at the reflux of the solvent. The potassium carbonate is filtered and washed with tetrahydrofuran. The filtrate is concentrated using a rotary evaporator under reduced pressure (5 kPa). 3.43 g of methyl[2-(2-bromophenyl)ethyl]carbamate are obtained in the form of a colorless thick oil

後処理

  1. customclose to 10° C
  2. customclose to 20° C.
  3. temperaturethe reaction mixture is heated for 2 h at the
  4. temperaturereflux of the solvent
  5. filtrationThe potassium carbonate is filtered
  6. washwashed with tetrahydrofuran
  7. concentrationThe filtrate is concentrated
  8. customa rotary evaporator under reduced pressure (5 kPa)

出典と根拠

ORDレコード
ord-81a595efa3224c76bcf90a4efefab9cb
出典データセット
uspto-grants-2013_02
特許番号
US08372864B2

関連ノート

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