Cesium carbonate → 6-(5-Chloro-4-(2-(isopropylsulfonyl)phenylamino)-pyrimidin-2-ylamino)-5-isopropoxy-2-(piperidin-4-yl)isoindolin-1-one

反応式

C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:22][C:21]3[C:16](=[CH:17][C:18]([N+:27]([O-])=O)=[C:19]([O:23][CH:24]([CH3:26])[CH3:25])[CH:20]=3)[C:15]2=[O:30])[CH2:10][CH2:9]1)=O)(C)(C)C.[H][H].Cl[C:34]1[N:39]=[C:38]([NH:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=2[S:47]([CH:50]([CH3:52])[CH3:51])(=[O:49])=[O:48])[C:37]([Cl:53])=[CH:36][N:35]=1.C(=O)([O-])[O-].[Cs+].[Cs+].CC1(C)C2C(=C(P(C3C=CC=CC=3)C3C=CC=CC=3)C=CC=2)OC2C(P(C3C=CC=CC=3)C3C=CC=CC=3)=CC=CC1=2.C(Cl)Cl.C(O)(C(F)(F)F)=O>CO.C1COCC1.[Pd].C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[Cl:53][C:37]1[C:38]([NH:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=2[S:47]([CH:50]([CH3:52])[CH3:51])(=[O:49])=[O:48])=[N:39][C:34]([NH:27][C:18]2[CH:17]=[C:16]3[C:21]([CH2:22][N:14]([CH:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)[C:15]3=[O:30])=[CH:20][C:19]=2[O:23][CH:24]([CH3:25])[CH3:26])=[N:35][CH:36]=1