Water → Methyl 2-bromo-3-cyclopropyl-3-oxopropanoate

HRID 389103

反応式

HRID 389103 の反応式
[CH:1]1([C:4](=[O:10])[CH2:5][C:6]([O:8][CH3:9])=[O:7])[CH2:3][CH2:2]1.Cl([O-])(=O)(=O)=O.[Mg+2].Cl([O-])(=O)(=O)=O.[Br:22]N1C(=O)CCC1=O.O>C(OCC)(=O)C>[Br:22][CH:5]([C:4]([CH:1]1[CH2:3][CH2:2]1)=[O:10])[C:6]([O:8][CH3:9])=[O:7]

参加物

6

反応物 4

HCID 962WaterHCID 24840Magnesium perchlorateHCID 67184N-bromobutanimideHCID 101300163-Cyclopropyl-3-Oxopropionic Acid Methyl Ester

生成物 1

HCID 58243876Methyl 2-bromo-3-cyclopropyl-3-oxopropanoate収率 106.8%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Methyl 3-cyclopropyl-3-oxopropanoate (2.0 g) and magnesium perchlorate (940 mg) were dissolved in ethyl acetate (20 ml), followed by stirring at room temperature for 5 minutes, and N-bromosuccinimide (2.76 g) was added thereto, followed by stirring at room temperature for 4 hours. Water was added thereto, followed by extraction with ethyl acetate, the organic layer was washed with water and saturated brine and was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to obtain, as a colorless oily product, methyl 2-bromo-3-cyclopropyl-3-oxopropanoate (3.32 g).

後処理

  1. stirringby stirring at room temperature for 4 hours
  2. extractionfollowed by extraction with ethyl acetate
  3. washthe organic layer was washed with water and saturated brine
  4. dry with materialwas dried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-867fd3f19a2344928aaca2959a94929d
出典データセット
uspto-grants-2013_02
特許番号
US08377923B2

関連ノート

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