N-Methylcyclohexylamine → N-cyclohexyl-N-methylethenesulfonamide
反応式
[CH3:1][NH:2][CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.Cl[CH2:10][CH2:11][S:12](Cl)(=[O:14])=[O:13]>C(Cl)Cl>[CH:3]1([N:2]([CH3:1])[S:12]([CH:11]=[CH2:10])(=[O:14])=[O:13])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1参加物
4
反応条件
- 温度
- 5 °C
実験手順
A mixture of N-methylcyclohexylamine (0.048 mol) and TEA (0.053 mol) in DCM (200 mL) was cooled in an ice bath to 5° C., and then a solution of 2-chloro-ethanesulfonyl chloride (0.048 mol, 97%) in DCM (20 mL) was added dropwise. The reaction mixture was stirred for 2 hours at room temperature and then was washed with H2O. The organic layer was separated, dried (MgSO4), and filtered, and the solvent was evaporated to yield the title compound as a residue.
後処理
- washwas washed with H2O
- customThe organic layer was separated
- dry with materialdried (MgSO4)
- filtrationfiltered
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-fb74971357bc4d2aaff209748951fcd0
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08383637B2
反応ノート
読み込み中…