Methanol → (3-Iodo-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid
反応式
[I:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:4]([CH2:11][C:12]([O:14]CC)=[O:13])[N:3]=1.CO.[Li+].[OH-]>C1COCC1>[I:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:4]([CH2:11][C:12]([OH:14])=[O:13])[N:3]=1参加物
5
実験手順
Ethyl (3-Iodo-pyrazolo[3,4-b]pyridin-1-yl)-acetate (11 g, 33 mmol, 1 equiv) was dissolved in 50 mL of THF and 50 mL of MeOH to the solution was added 40 mL of 1N LiOH for 3 h. The organic solvents were evaporated and the remaining aqueous phase was neutralized with 1N HCl to a pH of about 1 which resulted in the precipitation of the desired product as a white solid was filtered and air dried to give (3-iodo-pyrazolo[3,4-b]pyridin-1-yl)-acetic acid.
後処理
- customThe organic solvents were evaporated
出典と根拠
- ORDレコード
- ord-88254691a00b4fc99d883dd34ca24366
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08383630B2
反応ノート
読み込み中…