Acetic Acid → b-(Z)-2-ethoxy-3-{4-[6-(1-methyl-3-pentylureido)pyrid-2-yl]phenyl}acrylic acid

HRID 390592ノート

反応式

HRID 390592 の反応式
[OH-].[Li+].C(O/[C:6](=[CH:12]\[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([N:25]([CH3:34])[C:26]([NH:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])=[O:27])[N:20]=2)=[CH:15][CH:14]=1)/[C:7]([O:9]CC)=[O:8])C.[C:35](O)(=[O:37])[CH3:36].O>O1CCCC1.C(OCC)(=O)C>[CH3:36][CH2:35][O:37]/[C:12](/[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([N:25]([CH3:34])[C:26]([NH:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])=[O:27])[N:20]=2)=[CH:15][CH:14]=1)=[CH:6]\[C:7]([OH:9])=[O:8]

参加物

7

反応物 4

HCID 176Acetic AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 16224919ethyl (Z)-2-ethoxy-3-{4-[6-(1-methyl-3-pentylureido)pyrid-2-yl]phenyl}acrylate

生成物 1

HCID 86626075b-(Z)-2-ethoxy-3-{4-[6-(1-methyl-3-pentylureido)pyrid-2-yl]phenyl}acrylic acid

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
68 °C

実験手順

0.68 mL (0.68 mmol) of aqueous 1 M lithium hydroxide solution is added to a solution of 0.20 g (0.45 mmol) of ethyl (Z)-2-ethoxy-3-{4-[6-(1-methyl-3-pentylureido)pyrid-2-yl]phenyl}acrylate in 6 mL of tetrahydrofuran. The reaction mixture is stirred at 68° C. for 18 hours. After cooling, the reaction is worked up by addition of 0.68 mL (0.68 mmol) of aqueous 1 M acetic acid solution and 10 mL of water and extraction with ethyl acetate. The organic phases are combined, washed with saturated aqueous sodium chloride solution and then dried over magnesium sulfate. After filtration, the solvents are evaporated off.

後処理

  1. temperatureAfter cooling
  2. washwashed with saturated aqueous sodium chloride solution
  3. dry with materialdried over magnesium sulfate
  4. filtrationAfter filtration
  5. customthe solvents are evaporated off

出典と根拠

ORDレコード
ord-1d5f4a48c45345fc858485df7fc3e5cd
出典データセット
uspto-grants-2013_02
特許番号
US08383652B2

反応ノート

読み込み中…