Methyl iodide → (NZ)-3-methyl-N-[5-methyl-3-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-ylidene]imidazol-3-ium-1-carboxamide;iodide

HRID 390696ノート

反応式

HRID 390696 の反応式
[CH3:1][C:2]1[S:6]/[C:5](=[N:7]\[C:8]([N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)=[O:9])/[N:4]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:3]=1.[I:25][CH3:26]>C(#N)C>[I-:25].[CH3:26][N+:12]1[CH:13]=[CH:14][N:10]([C:8](/[N:7]=[C:5]2\[S:6][C:2]([CH3:1])=[CH:3][N:4]\2[C:15]2[CH:16]=[CH:17][C:18]([C:21]([F:24])([F:22])[F:23])=[CH:19][CH:20]=2)=[O:9])[CH:11]=1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 87450752(NZ)-N-[5-methyl-3-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-ylidene]imidazole-1-carboxamide

生成物 1

HCID 87447393(NZ)-3-methyl-N-[5-methyl-3-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-ylidene]imidazol-3-ium-1-carboxamide;iodide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

N-[(2Z)-5-methyl-3-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2(3H)-ylidene]-1H-imidazole-1-carboxamide (2.0 g, 5.68 mmol, Example 18A) in acetonitrile (10 mL) was treated with iodomethane (3 mL). The mixture was stirred at room temperature for five days, the solvent was evaporated, and the title product was used directly for the next step.

後処理

  1. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-c97093caa2754b079764acbc5cafc707
出典データセット
uspto-grants-2013_02
特許番号
US08383657B2

反応ノート

読み込み中…