Thionyl Chloride → 2,3-Dihydro-benzo[b]oxepine-4-carbonylchloride

HRID 391277ノート

反応式

HRID 391277 の反応式
[O:1]1[CH2:7][CH2:6][C:5]([C:8](O)=[O:9])=[CH:4][C:3]2[CH:11]=[CH:12][CH:13]=[CH:14][C:2]1=2.S(Cl)([Cl:17])=O>O1CCCC1>[O:1]1[CH2:7][CH2:6][C:5]([C:8]([Cl:17])=[O:9])=[CH:4][C:3]2[CH:11]=[CH:12][CH:13]=[CH:14][C:2]1=2

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 11116823HCID 11116823、化合物

生成物 1

HCID 866497862,3-Dihydro-benzo[b]oxepine-4-carbonylchloride

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

2,3-Dihydro-benzo[b]oxepine-4-carboxylicacid (2.3 mmol) was dissolved in 15 ml tetrahydrofuran. 0.7 ml of thionylchloride were added dropwise and the solution was stirred for two hours. The reaction was quenched by methanol. Methanol and thionylchloride were removed in vacuo yielding 340 mg of 2,3-Dihydro-benzo[b]oxepine-4-carbonylchloride. This was used for step E without further purification.

後処理

  1. customThe reaction was quenched by methanol
  2. customMethanol and thionylchloride were removed in vacuo

出典と根拠

ORDレコード
ord-51f21275dd8f428581af85e507df0333
出典データセット
uspto-grants-2013_02
特許番号
US08383838B2

反応ノート

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