Sodium Carbonate → HCID 59578402、化合物

HRID 391281

反応式

HRID 391281 の反応式
Br[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([O:10][CH3:11])[CH:3]=1.CC1(C)C(C)(C)OB([C:20]2[CH:21]=[N:22][CH:23]=[C:24]([CH:27]=2)[CH:25]=[O:26])O1.C(=O)([O-])[O-].[Na+].[Na+]>COCCOC.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH:25]([C:24]1[CH:27]=[C:20]([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([O:10][CH3:11])[CH:3]=2)[CH:21]=[N:22][CH:23]=1)=[O:26]

参加物

6

反応物 3

HCID 10340Sodium CarbonateHCID 49926405-(Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbaldehydeHCID 223467024-Bromo-2-methoxybenzonitrile

生成物 1

HCID 59578402HCID 59578402、化合物収率 90.2%

試薬・触媒・溶媒 2

HCID 178418397HCID 178418397、化合物触媒HCID 80711,2-Dimethoxyethane溶媒

反応条件

温度
90 °C

実験手順

A mixture of 4-bromo-2-methoxybenzonitrile (0.424 g, 2.000 mmol), 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinaldehyde (0.466 g, 2.000 mmol), tetrakis(triphenylphosphine)palladium(0) (0.058 g, 0.050 mmol) and sodium carbonate (2M in water, 2.00 mL, 4.00 mmol) in DME (50 mL) was heated to 90° C. for 6 h. After filtration through a pad of dry Na2SO4 and concentration, the residue was purified by column and yielded a colorless solid (430 mg). 1H NMR (400 MHz, CDCl3): δ 4.04 (s, 3H), 6.99 (s, 1H), 7.27 (d, J=4.7 Hz, 1H), 7.71 (d, J=7.9 Hz, 1H), 8.34 (t, J=2 Hz, 1H), 9.07 (d, J=2.36 Hz, 1H), 9.12 (d, J=1.9 Hz, 1H), 10.22 (s, 1H).

後処理

  1. filtrationAfter filtration
  2. concentrationthrough a pad of dry Na2SO4 and concentration
  3. customthe residue was purified by column

出典と根拠

ORDレコード
ord-a3372f93420842769c24bf88a86dccf3
出典データセット
uspto-grants-2013_02
特許番号
US08383827B2

関連ノート

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