(3-Bromo-5-nitrophenyl)methanol → (3-Amino-5-bromophenyl)methanol

HRID 391429

反応式

HRID 391429 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:11][OH:12])[CH:5]=[C:6]([N+:8]([O-])=O)[CH:7]=1>CO.[Pt](=O)=O>[NH2:8][C:6]1[CH:5]=[C:4]([CH2:11][OH:12])[CH:3]=[C:2]([Br:1])[CH:7]=1

参加物

4

反応物 1

HCID 14866972(3-Bromo-5-nitrophenyl)methanol

生成物 1

HCID 58993589(3-Amino-5-bromophenyl)methanol

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 887Methanol溶媒

実験手順

(3-Bromo-5-nitrophenyl)methanol (3.9 g, 16.8 mmol) in methanol (35 mL) was flushed with nitrogen, and treated with platinum (IV) oxide (390 mg). The flask was flushed with hydrogen and allowed to stir under an atmosphere of hydrogen for 1 h. The reaction was flushed with nitrogen, filtered through celite, and concentrated to afford 3.1 g (94%). 1H-NMR (CDCl3, 300 MHz) δ 6.95 (s, 1H), 6.80 (s, 1H), 6.79 (s, 1H), 4.61 (s, 2H). Mass spec.: 203.96 (MH)+.

後処理

  1. customThe flask was flushed with hydrogen
  2. customThe reaction was flushed with nitrogen
  3. filtrationfiltered through celite
  4. concentrationconcentrated
  5. customto afford 3.1 g (94%)

出典と根拠

ORDレコード
ord-e4f63e5b3b20495b971be59e1fb5bc9b
出典データセット
uspto-grants-2013_02
特許番号
US08383821B2

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