2,2-dimethoxyethyl N-benzyloxycarbonylglycine → 2,2-Dimethoxyethyl glycine

HRID 39249ノート

反応式

HRID 39249 の反応式
[CH3:1][O:2][CH:3]([O:20][CH3:21])[CH2:4][N:5](C(OCC1C=CC=CC=1)=O)[CH2:6][C:7]([OH:9])=[O:8]>C1COCC1.[Pd]>[CH3:21][O:20][CH:3]([O:2][CH3:1])[CH2:4][NH:5][CH2:6][C:7]([OH:9])=[O:8]

参加物

4

反応物 1

HCID 671854852,2-dimethoxyethyl N-benzyloxycarbonylglycine

生成物 1

HCID 193615392,2-Dimethoxyethyl glycine収率 77.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of compound 37 (425 mg, 1.43 mmol) dissolved in 20 mL of anhydrous THF in a Parr apparatus for hydrogenation, was added 160 mg of 10% Pd/C, the system was charged with 60 psi of H2, and the bottle was shaken for 2 h. The catalyst was filtered over Celite, washed with 20 mL of ethyl acetate and the combined filtrate was concentrated in vacuo to give 38 (180 mg, 77%). 1H NMR (400 MHz, CDCl3) δ 3.36 (s, 6H), 3.42 (s, 2H), 4.08 (d, J=5.3 Hz, 2H), 4.54 (t, J=5.3 Hz, 1H).

後処理

  1. additionthe system was charged with 60 psi of H2
  2. filtrationThe catalyst was filtered over Celite
  3. washwashed with 20 mL of ethyl acetate
  4. concentrationthe combined filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-3fb39e9d7c8241268885ef176626c218
出典データセット
uspto-grants-2013_09
特許番号
US08524691B2

反応ノート

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