Triethylamine → 2-(4-Ethylphenyl)-4,4-dimethyl-2-oxazoline

HRID 392805

反応式

HRID 392805 の反応式
[CH2:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][CH:4]=1)[CH3:2].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[NH2:31][C:32]([CH3:36])([CH3:35])[CH2:33]O.C(N(CC)CC)C>C(#N)C.CCCCCC.C(OCC)(=O)C.ClC(Cl)(Cl)Cl>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([C:7]2[O:9][CH2:33][C:32]([CH3:36])([CH3:35])[N:31]=2)=[CH:10][CH:11]=1)[CH3:2]

参加物

9

反応物 4

HCID 8471TriethylamineHCID 11776TriphenylphosphineHCID 118072-Amino-2-methyl-1-propanolHCID 120864-Ethylbenzoic Acid

生成物 1

HCID 128725592-(4-Ethylphenyl)-4,4-dimethyl-2-oxazoline

試薬・触媒・溶媒 4

HCID 5943Carbon Tetrachloride溶媒HCID 6342Acetonitrile溶媒HCID 8058Hexane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 4-ethylbenzoic acid (3.80 g) in anhydrous acetonitrile (100 mL) was added under a nitrogen atmosphere, triphenylphosphine (20 g), 2-amino-2-methyl-1-propanol (2.74 mL) and triethylamine (28.2 mL). The mixture was cooled on an ice bath and then tetrachloromethane (5.36 mL) was added. The reaction mixture was allowed to stand at room temperature and stirred for 18 hours. To the reaction mixture was added ethyl acetate and hexane and the precipitate was removed by filtration. The concentration of the filtrate left a residue, which was purified by column chromatography on silica gel (hexane/ethyl acetate/=9/1/ to 6/1) to give the subject compound (1.15 g).

後処理

  1. temperatureThe mixture was cooled on an ice bath
  2. customto stand at room temperature
  3. customthe precipitate was removed by filtration
  4. waitThe concentration of the filtrate left a residue, which
  5. customwas purified by column chromatography on silica gel (hexane/ethyl acetate/=9/1/ to 6/1)

出典と根拠

ORDレコード
ord-379ea6918f694918980ed6dce91f1921
出典データセット
uspto-grants-2004_10
特許番号
US06803372B2

関連ノート

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