Toluene → 4-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester chloroformate

HRID 39290

反応式

HRID 39290 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(Cl)([Cl:17])=O.C1(C)C=CC=CC=1>C1COCC1>[Cl:17][C:6]([OH:5])=[O:7].[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 3

HCID 1140TolueneHCID 6371PhosgeneHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

生成物 1

HCID 866555934-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester chloroformate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (201 mg, 1.0 mmol) in THF (2 mL) was added a 20% solution of phosgene in toluene (358 μL, 1.7 mmol). The reaction was stirred at room temperature for 1 hour. The reaction was concentrated under reduced pressure.

後処理

  1. concentrationThe reaction was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-b8798188cd69492386d462f7445ecae2
出典データセット
uspto-grants-2013_09
特許番号
US08524764B2

関連ノート

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