Toluene → 4-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester chloroformate
反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(Cl)([Cl:17])=O.C1(C)C=CC=CC=1>C1COCC1>[Cl:17][C:6]([OH:5])=[O:7].[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]参加物
5
実験手順
To a solution of 4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (201 mg, 1.0 mmol) in THF (2 mL) was added a 20% solution of phosgene in toluene (358 μL, 1.7 mmol). The reaction was stirred at room temperature for 1 hour. The reaction was concentrated under reduced pressure.
後処理
- concentrationThe reaction was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-b8798188cd69492386d462f7445ecae2
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524764B2
反応ノート
読み込み中…