Tetrahydrothiophene → 1-(3,3-Dimethyl-2-oxobutyl)thiolan-1-ium bromide

HRID 393500

反応式

HRID 393500 の反応式
[S:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:6][CH2:7][C:8](=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10].C(OCC)(=O)C>C(#N)C>[Br-:6].[O:13]=[C:8]([C:9]([CH3:12])([CH3:11])[CH3:10])[CH2:7][S+:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 1127TetrahydrothiopheneHCID 8857Ethyl AcetateHCID 21642Bromopinacolone

生成物 1

HCID 225645781-(3,3-Dimethyl-2-oxobutyl)thiolan-1-ium bromide収率 80.4%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

In 100 ml of acetonitrile was dissolved 11.8 g of tetrahydrothiophene, to the solution was gradually added 20 g of 1-bromo-3,3-dimethyl-2-butanone. The mixture was stirred at room temperature for 2 days to deposit powder. After adding 100 ml of ethyl acetate to the reaction solution, the powder was collected by filtration, washed with ethyl acetate and dried to obtain 24 g of 2-oxo-3,3-dimethylbutyltetrahydrothiophenium bromide.

後処理

  1. filtrationthe powder was collected by filtration
  2. washwashed with ethyl acetate
  3. customdried

出典と根拠

ORDレコード
ord-36e13cc4264d4906ba7117d5054220e7
出典データセット
uspto-grants-2004_10
特許番号
US06808862B2

関連ノート

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