(4-Nitrophenyl)acetic acid → Benzeneacetyl chloride, 4-nitro-

HRID 393848

反応式

HRID 393848 の反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[N+:7]([C:10]1[CH:15]=[CH:14][C:13](CC(O)=O)=[CH:12][CH:11]=1)([O-:9])=[O:8].CN(C=O)C>ClCCl>[N+:7]([C:10]1[CH:15]=[CH:14][C:13]([CH2:1][C:2]([Cl:4])=[O:3])=[CH:12][CH:11]=1)([O-:9])=[O:8]

参加物

5

反応物 3

HCID 4661(4-Nitrophenyl)acetic acidHCID 6228DimethylformamideHCID 65578Oxalyl chloride

生成物 1

HCID 6452210Benzeneacetyl chloride, 4-nitro-

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

3.75 ml (7.5 mmoles) of a 2M solution of oxalyl chloride in dichloromethane is added at 20° C. to a solution of 0.9 g (5 mmoles) of 4-nitrophenylacetic acid in a mixture composed of 10 ml of dichloromethane and 0.5 ml of DMF. After agitation for 30 minutes, the solution is concentrated under vacuum. The yellow oil obtained is used without additional purification in the following stage.

後処理

  1. concentrationthe solution is concentrated under vacuum
  2. customThe yellow oil obtained
  3. customis used without additional purification in the following stage

出典と根拠

ORDレコード
ord-a2c4d1ad5c0049ed90be11c40f056869
出典データセット
uspto-grants-2004_10
特許番号
US06809088B2

関連ノート

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