反応式
[CH2:1]([O:3][C:4](=[O:26])[CH:5]([O:22][CH:23]([CH3:25])[CH3:24])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13]CC2C=CC=CC=2)=[C:9]([F:21])[CH:8]=1)[CH3:2]>[Pd].C1COCC1>[CH2:1]([O:3][C:4](=[O:26])[CH:5]([O:22][CH:23]([CH3:25])[CH3:24])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([F:21])[CH:8]=1)[CH3:2]参加物
4
実験手順
0.5 g of 10% palladium on charcoal were added to a solution of 3.7 g of [rac]-3-(4-benzyloxy-3-fluoro-phenyl)-2-isopropoxy-propionic acid ethyl ester (10.26 mmol) in 30 ml of THF and the compound was stirred under an atmosphere of H2, at normal pressure and ambient temperature, until the absorption of gas stopped. After filtration of the catalyst and evaporation of the filtrate, 2.7 g of [rac]-3-(3-fluoro-4-hydroxy-phenyl)-2-isopropoxy-propionic acid ethyl ester were obtained as colorless viscous oil (97.3% of theory).
後処理
- filtrationAfter filtration of the catalyst and evaporation of the filtrate
出典と根拠
- ORDレコード
- ord-57fc810ee6c24904a01cb61137da40e9
- 出典データセット
- uspto-grants-2004_10
- 特許番号
- US06809110B2
関連ノート
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