Acrylonitrile → 3-(4-Methoxyphenoxy)propanenitrile

HRID 394669

反応式

HRID 394669 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.[C:10](#[N:13])[CH:11]=[CH2:12]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH2:12][CH2:11][C:10]#[N:13])=[CH:5][CH:4]=1

参加物

3

反応物 2

HCID 7855AcrylonitrileHCID 90154-Methoxyphenol

生成物 1

HCID 1142473-(4-Methoxyphenoxy)propanenitrile

実験手順

A mixture of 4-methoxyphenol (10 g: 80.5 mmol) and Triton B (2.29 ml:14.5 mmol:0.18 eq.) in acrylonitrile (50 ml) is heated at reflux for 48 hours. After the solvent has been partially removed, the products are extracted with ethyl acetate and washed with water and then with a 6N hydrochloric acid solution. The residual chestnut-brown oil is purified on a flash silica column eluted with an AcOEt/PE gradient.

後処理

  1. temperatureis heated
  2. temperatureat reflux for 48 hours
  3. customAfter the solvent has been partially removed
  4. extractionthe products are extracted with ethyl acetate
  5. washwashed with water
  6. customThe residual chestnut-brown oil is purified on a flash silica column
  7. washeluted with an AcOEt/PE gradient

出典と根拠

ORDレコード
ord-ddb496f603064baab815722b4982ba8d
出典データセット
uspto-grants-2003_08
特許番号
US06602903B2

関連ノート

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